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1975) Hibbs (1974); Keller (1974) (1981a) CHEMOTHERAPY AGENTS A N D MONONUCLEAR PHAGOCYTES 39 sulted in prolonged monocytopenia lasting at least 14 days. In the same study, hydrocortisone did not affect the number of macrophages already present in the peritoneal cavity, but the transit of mononuclear phagocytes from the circulation into the peritoneal cavity was arrested. When an inflammatory response in the peritoneal cavity of hydrocortisone-treated mice was induced by injection of newborn calf serum, the increase in the number of monocytes in the circulation and in the peritoneal cavity was suppressed.

T. (1960). Anrihiot. Annrt. 1959-1960, 230-235. , Grundin, R . , and Orrenius, S. (1974). R i o c l r m . B i ~ p l i y . \. ~. Coninirrn. 59, 334-339. Walker, M. , and Gehan, E. A. (1972). Proc. Anzer. Asoc. Crrnwr R P S . 13, 67. Walker, M. , and Hilton, J . (1976). Crrtic~rTrerrr. R q ) . 60, 725-728. Weinkam, R . , and Deen, D. F. (1982). Croicn. Rcas. 42, 1008-1014. Weinkam, R . J . , and Dolan, M. E. (1982). Proc. Am. soc. Concrr R r s . 23, 163. Weinkam, R . -S. (1979). J . M d . Clrcwi.

J . , and Herrer, T. C. Crrncrr Chrmother. Rep. 42, 9- 12. Wheeler, G. , Bowdon, B. J . , Grimsley, J. A . , and Lloyd, H . H. (1974). Crrnc,rr R e s . 34, 194-200. CHLOROETH Y LNITROSOUREA 33 Wheeler, G. , Bowdon, B. J . , and Struck, R. F. (1975a). 35, 2974-2984. Wheeler, K. , Williams. M. , Levin, V. A , , and Kabra, P. M. (1975a). Co/rwr R c t . 35, 1464- 1469. Wheeler, G . , Johnston, T. , Bowdon, B. J . , McCaleb, G . , Hill, D. J . , and Montgomery, J. A. (1977). Biochcwr. Plrnrtmrcd. 26, 331-2336, Wheeler.

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