By Sudarshan K. Malhotra

A part of a sequence which goals to hide contemporary wisdom within the box of neural technology, this quantity discusses such issues as: the molecular bases of nerve regeneration; plasticity of descending spinal pathways in constructing mammals; and improvement of the mammalian auditory hindbrain.

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Their studies have shown that VIP increases the survival of dissociated embryonic spinal cord neurons in vitro, an effect that can be blocked with TTX. In contrast, GHRH significantly decreases neuronal survival in thesesame cells in culture (Brenneman and Foster, 1987). These findings demonstrate that the survival-promoting effects of VIP are confined to a critical period of neuronal growth in culture. In this study, the critical period occurs between 7 and 21 days after plating and is significant because it relates to the period of normally occurring cell death.

This developmental window (E l-E3) is common for excitatory cholinergic and catecholaminergic elements as well as inhibitory GABAergic elements. VI. CONCLUSIONS Considerable evidence is now available concerning the early presence of several neuropeptides during early neuroembryogenesis. The high but transient endogenous levels of some peptides such as SRIE VIE SP, NPY, and NT has led to the conclusion that these peptides are involved in early mechanisms of neuronal differentiation and growth. Although the research on the ontogeny of neuropeptide receptors is not extensive, the decline in receptor binding sites from development to adulthood is further supportive evidence that neuropeptides have neuromodulatory actions during early neuroembryogenesis.

Their studies have shown that VIP increases the survival of dissociated embryonic spinal cord neurons in vitro, an effect that can be blocked with TTX. In contrast, GHRH significantly decreases neuronal survival in thesesame cells in culture (Brenneman and Foster, 1987). These findings demonstrate that the survival-promoting effects of VIP are confined to a critical period of neuronal growth in culture. In this study, the critical period occurs between 7 and 21 days after plating and is significant because it relates to the period of normally occurring cell death.

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