By S. González-Moreno

This e-book stories present examine in peritoneal malignant dissemination, from its pathogenesis and molecular mechanisms to the most recent scientific trials. The publication covers the necessities of perioperative intraperitoneal chemotherapy and sleek histopathological evaluation of peritoneal floor malignancy. The book’s ancient point of view at the unfolding of latest wisdom issues the way in which for destiny examine. individuals contain major specialists, between them the pioneers who gave delivery to this new period in oncology.

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Additional resources for Advances in Peritoneal Surface Oncology (Recent Results in Cancer Research, Volume 169)

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Furthermore, combining the conventional method with immunocytological studies provided more sensitive results than the conventional staining alone [33]. It has been shown that quantification of CEA protein levels in peritoneal wash fluid can be a sensitive and useful predictor of peritoneal recurrence. Nishiyama et al. reported that CEA levels in peritoneal washings were statistically independent of those in sera and could more reliably predict the presence of peritoneal dissemination than a cytological study [35].

In oesophageal and colorectal cancer, these crevices are the preferential area of serosal involvement 27 difference in the microanatomical structure in these areas, making the serosal surface more prone to penetration by tumour [14]. Macroscopically, serosal involvement can be subtle and a telltale sign is loss of the ‘shiny’ appearance of the serosa, possibly associated with telangiectatic blood vessels. More obvious evidence of peritoneal involvement is provided by a fibrinous exudate and a coarse irregular serosa.

These could have been artefactually misplaced into the lumen by the act of painting At the time of macroscopic and microscopic assessment, it is critical that the pathologist is able to accurately differentiate margin involvement from peritoneal involvement. This is especially the case in oesophageal, colonic and rectal cancer: margin involvement may well be used as a surrogate marker for the quality of surgery. This is one of the prime reasons behind our recommendation that the serosal surface should never be painted at the time of macroscopic assessment (Fig.

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